Chondromyxoid fibroma is an uncommon benign cartilaginous tumor of the bone. Radiological evaluation of a chondromyxoid fibroma published. Tumors located in the distal extremities such as the hands or feet may only present clinically with signs of painless swelling 5. Less common lesions include fibrous dysplasia, fibroxanthoma nonossify ing fibroma, chondromyxoid fibroma, solitary bone cyst, fibrous histiocytoma, eosinophilic granuloma, and even osteosarcoma. Huge chondromyxoid fibroma of the right iliac wing with. It is usually located eccentrically in distal femur or proximal tibia metaphysis. In many cases, the tumor will destroy portions of the bone and aggressively grow, pushing into the surrounding soft tissues.
An adult male patient at the age of 28 suffered a fracture of the lateral malleolus due to an eccentric, lytic, lobular lesion in the epiphysis, during a basketball match. Most cases are characterised by grm1 gene fusion or promoter swapping. A primary chondromyxoid fibroma cmf arising from sternum is quite uncommon tumor in thoracic surgery. Smaller lesions are typically located in the cortex of long bones. We analyzed rapid romanowsky and papanicolaoustained slides with a respect to overall cellularity, the presence of hypercellular chondromyxoid fragments hcfs, nuclear atypia, cytoplasmic features, and the presence of giant cells. Chondromyxoid fibroma cmf is one of the rarest benign tumors of cartilaginous origin. Chondromyxoid fibroma is a type of cartilaginous tumor most cases are characterised by grm1 gene fusion or promoter swapping. Males have a higher incidence, with no other demographic bias 3. Removal of giant sternal tumors requires extensive resection of the anterior chest wall, and results in deformity and paradoxical movement.
An additional peak of incidence has been observed between 50 and 70 years of age. Jaffe and lichtenstein first described the condition in 1943. Fineneedle aspiration biopsy of chondromyxoid fibroma. Radiographic and histologic patterns of calcification in chondromyxoid fibroma. Activating rearrangements of grm1 metabotropic glutamate receptor 1. Chondromyxoid fibromas are rare, benign tumours that resemble cartilage, initially arising in the cortex of affected bones most commonly the lower limbsy their documented incidence is less than 1 % of all primary bone tumours approximately 2% of all benign bone tumours with males and females being equally affectedy. Chondromyxoid fibroma cmf is a rare, benign bone tumour. Chondromyxoid fibroma of the frontal bone tatsuo morimura, 12 atsuhisa nakano, 1 tsuyoshi matsumoto, 1 and eiichi tani1 summary.
Chondromyxoid fibromas cmfs are extremely rare, benign cartilaginous neoplasms that account for benign bone tumor arising in young adults. Plain skull films showed a round radiolucent mass with a sclerotic margin. Chondromyxoid fibroma is the least commonly occurring bone tumor, accounting for approximately 1% of all biopsied primary bone tumors 7, 32. It has a cartilagelike matrix composed of chondroid, fibrous, and myxoid areas in varying proportions. Chondromyxoid fibroma with secondary aneurysmal bone cyst in. Chondromyxoid fibroma of bone, a clinicopathologic study of thirtytwo cases. Bullous lesions in patient with lupus explore this issuefebruary 2016 her chest radiograph revealed no infiltrates. The diagnosis of cmf depends upon its characteristic histological appearance like a lobular pattern with stellateshaped cells. Treatment for cmf requires surgery to remove the tumor. Chondromyxoid fibroma is a rare benign tumor that usually occurs in the long bones and rarely affects the sinonasal region. Chondromyxoid fibroma is a rare, benign tumor of bone that represents fewer than 1% of all benign and malignant tumors of bone. It was dense on plain ct scan and showed no convincing contrast enhancement. Clinically, it is characterized by a lobular growth pattern and. Get a printable copy pdf file of the complete article 647k, or click on a page image below to browse page by page.
It is associated with high local recurrence rates with a small risk chondromyxoid matrix in a distinctive histological pattern. Both clinically and histologically, it is a difficult diagnosis and can be confused with malignant lesions. With contrast injection, the central portion of the lesion may show no enhancement due to the myxoid component. A 35yearold man visited us with a chief complaint of painful swelling of the finger. It usually affects the metaphyseal region of long bones of patients in their first or second decade of life. Bullous lesions in patient with lupus explore this issuefebruary 2016 her chest radiograph revealed no.
In 1948, the tumor was first described by jaffe and lichtenstein as a lesion derived from cartilageforming tissue and composed of various proportions of chondroid, fibrous, and myxoid tissues. Chondromyxoid fibroma of bone, with emphasis on its morphological relationship to benign chondroblastoma. Abstract chondromyxoid fibroma is a benign, although potentially aggressive tumor, with a cartilagelike matrix, accounting for approximately 1% of all bone tumors. Chondromyxoid fibroma is a benign, although potentially aggressive tumor, with a cartilagelike matrix, accounting for approximately 1% of all bone tumors. Chondromyxoid fibroma is a type of cartilaginous tumor. Huge chondromyxoid fibroma of the right iliac wing with tremendous soft tissue extensions hosameldeen mostafa ali, md department of radiology, benha university, benha, egypt address correspondence to. Surgical management of a giant sternal chondromyxoid. Fineneedle aspiration biopsy of chondromyxoid fibroma an. Sep 23, 2016 chondromyxoid fibroma cmf is a benign, locally aggressive tumor of cartilaginous origin and accounts for less than 0. July 27, 2017 056 the tumor may be discovered incidentally during radiography 1. Chondromyxoid fibroma definition of chondromyxoid fibroma. It is associated with high local recurrence rates with a small risk sep 24, 2018 chondromyxoid fibroma. To our knowledge, this case report represents the first description of cmf involving an extragnathic site in the facial skeleton exclusive of the cranium.
Sep 12, 2014 chondromyxoid fibroma cmf is a rare, benign bone tumour. Open access publication chondromyxoid fibroma of the foot. Most chondromyxoid fibromas are small 1 to 4 cm, round or ovalshaped tumors. Rarer locations include the fibula, scapula, vertebrae and ribs 3. The possibility of chondromyxoid fibroma should always be considered when a focal bone lesion is evaluated that has geographic bone destruction, a sclerotic rim, lobulated margins, and septation. To our knowledge, this is the first reportable case of cmp presenting with undifferentiated connective tissue. Since 1948, when jaffe and lichtenstein first recognized this tumor as a distinct entity, and. Chondromyxoid fibroma of the finger pubmed central pmc. Chondromyxoid fibroma cmf is a rare benign bony tumour. Metaphysis of long tubular bones, small bones of feet or any bone, skull base clivus. It occurs most frequently in the metaphysis of long tubular bones, and an epiphyseal location is exceedingly rare. Chondromyxoid fibroma is a benign tumor of bone that is characterized by chondroid and myxoid differentiation and by ultrastructural and immunohistochemical evidence of chondral origin.
Soni r, kapoor c, shah m, turakhiya j, golwala p 2016 chondromyxoid fibroma. Chondromyxoid fibroma cmf is a benign, locally aggressive tumor of cartilaginous origin and accounts for less than 0. A rare case of epiphyseal chondromyxoid fibroma of the. The differential diagnosis included the chondroblastoma, the aneurysmal cyst and.
It has a predilection for men in the second and third decades of life with the metaphyseal regions of the long bones of the lower extremities as the favored sites of occurrence. May 12, 2014 surgical excision is the firstline choice for chondromyxoid fibroma, for which only simple curettage is performed or a bone graft is used for filling the cavitary defect following curettage. A chondromyxoid fibroma cmf is an extremely rare benign cartilaginous neoplasm which accounts for chondromyxoid fibroma of the foot. Well circumscribed, hypocellular lobules of poorly formed hyaline cartilage composed of chondroblasts with abundant pink cytoplasm and myxoid tissue with fibrous septae containing spindle cells and osteoclasts. Complete local excision with tumorfree margins avoids the recurrence of cmf, the underlying tumor in this case report. Jan 01, 2009 chondromyxoid fibroma cmf is a rare neoplasm constituting less than 1% of all bone tumors. Despite a characteristic radiographic appearance, chondromyxoid fibroma with atypical radiographic findings may mimic more common tumors. It is most commonly found in the metaphysis of long bones and usually presents in the second or third decade of life. To describe the mr findings of chondromyxoid fibroma. Concomitant lupus with features of scleroderma, castleman disease rheumatology case report. A case of chondromyxoid fibroma cmf involving the zygoma is presented. In xrays, they are often surrounded by a white sclerotic rim. The diagnosis of cmf depends upon its characteristic histological appearance like a lobular pattern with stellateshaped cells in a myxoid or.
Chondromyxoid fibroma cmf is an extremely rare, benign cartilaginous tumor that makes up 0. To present a case of chondromyxoid fibroma of the nasal bone and discuss its presentation. Chondromyxoid fibroma is a very rare benign cartilaginous tumor representing less than 0. Chondromyxoid fibroma cmf is one of the rarest of bone tumors, accounting for less than 1% of all bone tumors. The treatment of the secondary abc is based on the appropriate treatment for the underlying tumor. A 40yearold female presented a progressively enlarging mass of her anterior chest wall. Chondromyxoid fibromas are rare, benign tumours that consist of immature myxoid mesenchymal tissue with features of primitive cartilaginous differentiation. Mri of chondromyxoid fibroma article pdf available in acta radiologica 528.
We present here an unusual case of a chondromyxoid fibroma that occurred in the epiphysis of the proximal tibia with an open growth plate. Chondromyxoid fibroma, cmf, is the least common benign cartilaginous tumor composed of chondroid and myxoid matrix. Chondromyxoid fibroma may occur anywhere in the skeleton, but almost half of the cases occur around the knee. Chondromyxoid fibroma cmf is a benign tumor of cartilagenous origin and rarest of all bone tumors. This article is from archives of plastic surgery, volume 41. Chondromyxoid fibroma is a rare benign primary bone tumor of cartilage. This is an advanced case of a benign chondromyxoid fibroma. It is a benign noncancerous tumor that most often develops in older children and young adults under 30 years of age.
It is composed of a mixture of chondroid, myxoid, and fibrous tissues. The lesion is never purely epiphyseal, but may extend into the subchondral b. Eight new cases are added, 4 of which exhibited unusual size andor focal microscopic calcification, pathologic fracture, diaphyseal location. Pdf chondromyxoid fibroma cmf is a rare benign mesenchymal tumor of the bone. Upon history taking, we found that the mass had formed 7 to 8 years before and had since grown. Chondromyxoid fibroma with secondary aneurysmal bone cyst. Primary chondromyxoid fibroma of the sternum is quite rare, with only six cases documented in the literature see table 1. Tinu syndrome with concomitant synovitis rheumatology case report. The most commonly affected area is the metaphysial region of the proximal tibia and the distal femur 2. We describe the cytologic features of chondromyxoid fibroma in fineneedle aspiration biopsy specimens in 4 patients.
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